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Return-Path: <bounces+13288428-34de-dr.sultan=jack.ngo@em3451.selectscience.com> Delivered-To: dr.sultan@jack.ngo Received: from mocha3025.mochahost.com by mocha3025.mochahost.com with LMTP id eMkBEpHtVmJc9gIAaMJ/gg (envelope-from <bounces+13288428-34de-dr.sultan=jack.ngo@em3451.selectscience.com>) for <dr.sultan@jack.ngo>; Wed, 13 Apr 2022 11:34:41 -0400 Return-path: <bounces+13288428-34de-dr.sultan=jack.ngo@em3451.selectscience.com> Envelope-to: dr.sultan@jack.ngo Delivery-date: Wed, 13 Apr 2022 11:34:41 -0400 Received: from o1.ptr5290.selectscience.com ([167.89.92.117]:20924) by mocha3025.mochahost.com with esmtps (TLS1.2) tls TLS_ECDHE_RSA_WITH_AES_128_GCM_SHA256 (Exim 4.94.2) (envelope-from <bounces+13288428-34de-dr.sultan=jack.ngo@em3451.selectscience.com>) id 1nef10-000tWo-7j for dr.sultan@jack.ngo; Wed, 13 Apr 2022 11:34:41 -0400 DKIM-Signature: v=1; a=rsa-sha256; c=relaxed/relaxed; d=selectscience.com; h=mime-version:from:subject:content-type:content-transfer-encoding:to; s=s1; bh=isLm5Z0OVPK7s4VU7+VvajxQJVqC9EQSm4AasNtYKIU=; b=dMIWbCW7r+1Q+Om8cvk/6yQBTnN3z+CqRSXF1AnzvlORBWezHsgJZZCkz1+66XExDt+J F0kjtb7d6xf5WTa9rMQw/nHN7oHM1zItdtKSdxsnNDUkf2NDiKDjFEBKv+J55bxNF40ZRp XfcPkpLWVrBBYcAAtFLOy8bGFum6T4pOqN2KgKWaVTW/+Rr25rsJGvLlegtA8z9Lhybete 5OyDXTcSCBA88tY5+gF3D2fCrPPWex78h1wbkWs3tF/7dui+mxLh7qiS84YJhVa+Wqi0Ze +RUE4c7BNwBSE8hM8tnhw9Ngu+0fz62HhTqqZQrNyIREwEPd633Q2z5V9yJe+zUA== Received: by filterdrecv-7f6dffff49-pr67t with SMTP id filterdrecv-7f6dffff49-pr67t-1-6256ED50-1 2022-04-13 15:33:36.338352009 +0000 UTC m=+581928.698587679 Received: from SS-WEB01 (unknown) by geopod-ismtpd-4-2 (SG) with ESMTP id S9SAupjyRKOyRVk_KBLk3A for <webinars@selectscience.com>; Wed, 13 Apr 2022 15:33:35.853 +0000 (UTC) MIME-Version: 1.0 From: Charlie Carter <webinars@selectscience.com> Date: Wed, 13 Apr 2022 15:33:59 +0000 (UTC) Subject: Safe & effective serial killers of solid tumors [CAR T cell webinar] Content-Type: text/html; charset=us-ascii Content-Transfer-Encoding: quoted-printable Message-ID: <S9SAupjyRKOyRVk_KBLk3A@geopod-ismtpd-4-2> X-SG-EID: =?us-ascii?Q?aWD1EYVVAMUKgUgnBNhErXGaZDsv72s6nINH7cSMRWpaUMWZIGdSgWxWG1nkOa?= =?us-ascii?Q?e9NZq5sQKTPPKhTUT8t=2FcBMImfHFg+rZ5LElIx0?= =?us-ascii?Q?ks9oD78l9f0qHgGaYc48m+K3MtmdHSeSh=2FbdJh5?= =?us-ascii?Q?we752eg5HeICCFAi=2FJoDq=2FcCk5m33On7VhdLESE?= =?us-ascii?Q?o1Av17eoZhEpX=2FNHBEsvple9SVqrH6yvvCCnAcM?= =?us-ascii?Q?Cs4kwH2gnVZxtLd64hKHCKZmxskmj+i+z630URe?= =?us-ascii?Q?8C71O2m2Uyb1o8mNEWTIg=3D=3D?= To: dr.sultan@jack.ngo X-Entity-ID: LHjqSk4arHVPSAxn7el6bQ== <!--preheader start--><!--[if !mso 9]><!--><p><span style=3D"display:none != important; visibility:hidden;opacity:0;color:transparent;height:0;width:0;"= >Register for free today &nb= sp; </span></p><div style=3D"display: none; m= ax-height: 0px; overflow: hidden;"> ‌ ‌ ‌&nbs= p;‌ ‌ ‌ ‌ ‌ ‌ &= zwnj; ‌ ‌ ‌ </div><!--<![endif]--> <!--p= reheader end--><!--start of promo--><p><span style=3D"text-align: left; col= or: rgb(0, 0, 0); font-family: Calibri, sans-serif; font-size: 11pt;= ">Dear Colleague,<br /><br /> This is a reminder for you to attend our upc= oming <a href=3D"http://www.selectscience.net/go/?itemID=3D79&itemTypeID=3D= 4&linkID=3DCTA1&mailID=3D18434&email=3Ddr.sultan@jack.ngo&URL=3Dhttps%3A%2F= %2Fview6.workcast.net%2Fregister%3Fcpak%3D9778500048429616%26referrer%3DSel= ectScience-promo-2" target=3D"_blank">free webinar:</a> <br /><br /><str= ong><a href=3D"http://www.selectscience.net/go/?itemID=3D79&itemTypeID=3D4&= linkID=3DCTA2&mailID=3D18434&email=3Ddr.sultan@jack.ngo&URL=3Dhttps%3A%2F%2= Fview6.workcast.net%2Fregister%3Fcpak%3D9778500048429616%26referrer%3DSelec= tScience-promo-2" style=3D"text-decoration: none; color: #000000" target=3D= "_blank"><span><u>Bispecific-antibody-armed, metabolically enhanced headles= s CAR T cells: Safe and effective serial killers of solid tumors</u></span>= </a></strong><br />Wednesday, 27 April, at 16:00 BST / 17:00 CEST / 11:00 E= DT / 08:00 PDT<br /><br /> <a href=3D"http://www.selectscience.net/go/?i= temID=3D79&itemTypeID=3D4&linkID=3DCTA3&mailID=3D18434&email=3Ddr.sultan@ja= ck.ngo&URL=3Dhttps%3A%2F%2Fview6.workcast.net%2Fregister%3Fcpak%3D977850004= 8429616%26referrer%3DSelectScience-promo-2" target=3D"_blank">In this webin= ar</a>, Dr. Archana Thakur will present an exciting talk about overcoming m= ajor challenges with metabolically enhanced headless CAR T (hCAR T) cells a= rmed with bispecific antibodies (bsAbs). <br><br /> Key learning objec= tives: </span></p> <ul> <li style=3D"text-align: left; color: rgb(0,= 0, 0); font-family: Calibri, sans-serif; font-size: 11pt;">BsAb-arm= ed hCAR T cells are superior to non-genetically modified T cells armed with= bsAbs and mediate superior levels of cytotoxicity directed at all tested s= olid tumor lines.</li> <li style=3D"text-align: left; color: rgb(0, 0, 0= ); font-family: Calibri, sans-serif; font-size: 11pt;">The hCAR T ce= lls killed multiple tumor lines significantly better than control T cells a= nd secreted Th1 cytokines/chemokines at effector to target ratio (E:T) of 2= :1 or 1:1.</li> <li style=3D"text-align: left; color: rgb(0, 0, 0); fon= t-family: Calibri, sans-serif; font-size: 11pt;">HER2 hCAR T cells s= erially killed tumor targets up to 14 days and continued to kill under in v= itro hypoxic conditions.</li> <li style=3D"text-align: left; color: rgb(= 0, 0, 0); font-family: Calibri, sans-serif; font-size: 11pt;">Sequen= tial targeting of positive tumors showed significantly increased cytotoxici= ty compared to single antigen targeting.</li> <li style=3D"text-align: = left; color: rgb(0, 0, 0); font-family: Calibri, sans-serif; font-si= ze: 11pt;">In this study, the researchers used Agilent Seahorse XF, Agilent= xCELLigence RTCA, and Agilent NovoCyte Flow Cytometer.</li> </ul>= <table><tbody><tr><td style=3D"background-color: #36b156; padding: = 10px 10px 10px 10px;"><a href=3D"http://www.selectscience.net/go/?itemID=3D= 79&itemTypeID=3D4&linkID=3DCTA4&mailID=3D18434&email=3Ddr.sultan@jack.ngo&U= RL=3Dhttps%3A%2F%2Fview6.workcast.net%2Fregister%3Fcpak%3D9778500048429616%= 26referrer%3DSelectScience-promo-2" style=3D"text-decoration: none; color: = #ffffff; font-family: Arial;" target=3D"_blank"><strong>Register now »= ;</strong></a></td></tr></tbody></table><p><span style=3D"text-align: left;= color: rgb(0, 0, 0); font-family: Calibri, sans-serif; font-size: 11pt;"><= strong> All webinar participants can request a certificate of attendance, i= ncluding a learning outcomes summary, for continuing education purposes &md= ash; </strong><a href=3D"http://www.selectscience.net/go/?itemID=3D79&item= TypeID=3D4&linkID=3DCTA5&mailID=3D18434&email=3Ddr.sultan@jack.ngo&URL=3Dht= tps%3A%2F%2Fview6.workcast.net%2Fregister%3Fcpak%3D9778500048429616%26refer= rer%3DSelectScience-promo-2" style=3D"font-family: Calibri, sans-serif; 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